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BPC-157 is a synthetic peptide derived from a sequence originally studied within protective peptide signaling pathways

Thus, although the combination of anti-complement therapies with other anti-cancer agents should be further investigated, the increasing number of studies that demonstrate the improved antitumor responses obtained combining complement inhibitionand in particular C5aR1 inhibitionwith chemotherapy and/or immunotherapy, together with our present results on paclitaxel-mediated C5aR1 activation, further sustain that a combined treatment with paclitaxel and C5aR1 inhibitors could be a promising therapeutic approach, not only to prevent CIPN and HSRs, but also to potentially obtain a synergistic effect on tumor progression

The mTOR signaling pathway plays a vital role in enterocyte growth, proliferation, and regeneration (67, 68), and thereby being conducive to the recovery of the small intestinal mucosa after damage (69, 70)

doi: 10.1089/ars.2020.8151 84 MorenoM

Patients should be aware that hydroxocobalamin may cause side effects such as nausea, vomiting, and diarrhea