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The nuclear factor-kappa B (NF-B) pathway-critical for inflammationis hyperactivated in M1 macrophages, leading to sustained cytokine production (93, 94)

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This ability to stimulate the ERK signaling may have physiologic and clinical relevance in modulating tissue homeostasis and may be involved in diseases such as hypertension and benign prostatic hyperplasia, among others (Villalobos-Molina et al., 1999

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10.3389/fphar.2024.1418824 67 WangJ.ZengL.ZhangY.QiW.WangZ.TianL.et al (2022)