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Putrescine acts as an antagonist, whereas spermidine and spermine act as agonists, regulating the activity of N-methyl-d-aspartate (NMDA)-type glutamate receptors 50

Sands JM, Layton HE

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Approximately 98% of the body's L-carnitine storage is stored in the muscles, the heart muscle and in the brain, with small amounts still being detectable in the liver and blood

The administration of acetyl-l-carnitine along with MA (increasing from 1 to 5 mg/kg, i.p.) for 10 days was shown to attenuate the severity of symptoms caused by non-use of the drug during the subsequent 10-day withdrawal period in Wistar rats 45