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Oral minoxidil, even at the low doses used for hair loss, carries a slightly different risk profile, including fluid retention, heart palpitations in rare cases, and unwanted body hair growth

Guzik TJ, Chen W, Gongora MC, Guzik B, Lob HE, Mangalat D, Hoch N, Dikalov S, Rudzinski P, Kapelak B, Sadowski J, Harrison DG (2008) Calcium-dependent NOX5 nicotinamide adenine dinucleotide phosphate oxidase contributes to vascular oxidative stress in human coronary artery disease

Most of what we know comes from lab cells and tissue models, not large, longterm human studies, so this use case should be seen as an experiment, not a guarantee

found that CoQ 10 increased the fatty acid oxidation through AMPK-mediated peroxisome proliferator-activated receptor-(PPAR-) induction in 3T3-L1 preadipocytes [30]

When your body is detoxing internally, your skin may be more sensitive externally