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1 Introduction Mitochondria are organelles in almost all eukaryotic cells, performing essential functions such as ATP production, calcium signaling, lipid biogenesis, oxidative stress regulation, and apoptosis

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Myeloid-like transcriptional features emerge in RMC liver metastases after treatment with nivolumab plus ipilimumab To elucidate the mechanisms behind the observed hyperprogression, we first performed post-hoc single-cell RNA sequencing (scRNA-seq) on immunotherapy-nave fresh tumor biopsy tissues from 7 patients with RMC, as well as on tissues collected immediately following progression on nivolumab plus ipilimumab from 2 patients with RMC (Fig