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When drug interactions associated with protein binding displacement and clinically important effects have been studied, it has been found that the displacing drug is also an inhibitor of clearance, and it is the change in clearance of the unbound drug that is the relevant mechanism explaining the interaction

doi: 10.1371/journal.ppat.1009220 23 GengR.DaiM.WangY.LiH

doi:10.1159/000133675

Guo et al., 2020

Biotin/avidin-HRP signal amplification was achieved using the ABCE lite Kit (Vector Laboratories) according to the manufacturers instructions
