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Currently, many authors suggest mild copper deficiency as a causative factor in AD and possibly other neurodegenerative disorders [26, 27]

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Copper-triggered aggregation of ubiquitin

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Whether parkin has a direct, negative effect on GR activity, such as through physical binding or, possibly through a form of ubiquitylation not yet detected by us [45], or an indirect effect via the redox state of cellular metabolites (e.g., the ratio of NADP + :NADPH/H + ), remains to be elucidated