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doi: 10.1111/j.1749-6632.1998.tb10696.x

Introduction Chronic cholestatic syndrome characterized by fibrosing inflammation in the intrahepatic and extrahepatic bile duct onset usually insidious leads to narrowing and, eventually, obliteration of the bile ducts Cause of primary sclerosing cholangitis (PSC) is unknown PSC occurs most often in young men ( 50% typical of obstructive pattern no urine urobilinogen low urine urobilin Endoscopic retrograde cholangiography (ERCP) give the biliary tree an irregular beaded appearance Treatment Liver transplantation prior to liver failure is a possibility in selected cases Prognosis, Prevention, and Complications Prognosis is poor May result in liver failure, cirrhosis, cholangiocarcinoma

It involves the regulation of sex hormone levels, growth factors, and anti-epithelial cell apoptosis processes, demonstrating the'protective effect of XJP on the prostate tissue as well as PSA, DHT, EGF, bFGF, VEGF, Bax, caspase-3, TGF-1, and IGF-1 serum levels in BPH rats

In recent years, the anti-inflammatory effect of PDE4 inhibitors has been shown to be mainly related to PDE4B while PDE4D is related to side effects such as digestive tract symptoms