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The inflammation begins mostly in the childhood or at juvenile age

The compact and symmetric structure of rosmarinic acid (Table 1) binds specifically to A, inhibits polymerization into the fibrillar form, and inhibits tau aggregation [170,173], imparting protection in AD and other neurogenerative conditions

10.1016/j.joim.2025.03.002 Summary Keywords Swertiamarin, (R)-Gentiandiol, (S)-Gentiandiol, non-alcoholic fatty liver disease, UPLC-Q-TOF/MS, Chinese medicine monomers Citation Sun Y, Cui F, Tang S, Li P, Xu Y, Li H, Wang Y, Li X, Zhang M, Ma R, Li X, Xu H, Wang Y, Zhang H and Wang Z (2025) Mechanism of swertiamarin and novel nitrogen-containing metabolites ( R )-Gentiandiol and ( S )-Gentiandiol in treating non-alcoholic fatty liver disease in rats: an untargeted metabolomics study based on UPLC-Q-TOF/MS

Canagliflozin reduces chemoresistance in hepatocellular carcinoma through pkm2-C-myc complex-mediated glutamine starvation

Cytotoxicity assays conducted on 3T3 fibroblasts, C2C12 myotubes, PC12 neurons, and RAW macrophages, demonstrated that neither Au nanospheres nor Au-PX-PLGA (0.010.5 mg/mL) caused significant toxicity, with cell viability remaining above 95%