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In MASLD, reduced SIRT1 activity leads to hyperacetylation and stabilization of PLIN2 and PLIN3, effectively locking lipid droplets and impairing lipophagic clearance, exacerbating triglyceride accumulation

Simultaneously, TEC-specific PRMT1 KO mice were used to construct a CaOx crystal-induced kidney-injury mouse model, and the KO efficiency was detected using WB and DNA agarose gel electrophoresis (Fig

However, the major challenge is synthesis and storage of large-scale nanotherapies

It remains to be determined whether treatment with HGF could be used to mobilize satellite cells in situations of inactivity, such as atrophy or cachexia