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Willett WC

Chromosomal localization, structure, and regulation of the UGT2B17 gene, encoding a C19 steroid metabolizing enzyme

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In a phase 2 study involving 21 patients with recurrent rGB, anlotinib combined with temozolomide demonstrated efficacy, achieving a median progression-free survival (PFS) of 7.3 months and a median overall survival (OS) of 16.9 months ( Regorafinib, a pankinase inhibitor, was initially tested as monotherapy on rGB patients in a phase 2 trial, which showed a survival benefit when compared to CCNU ( 3 CDK-Rb targeting agents Targeting this pathway in oncology has been primarily limited to CDK4/6 inhibitors

Steriade C, Andrade DM, Faghfoury H, Tarnopolsky MA, Tai P