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Tirzepatide selectively binds to and activates both the GIP and GLP-1 receptors, the targets for native GIP and GLP-1

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During GBM development, various aberrations in epigenetic modifications, including DNA methylation, histone acetylation, and N6-methyladenosine (m6A) RNA modification, occur [16]

doi:10.1016/j.pharmthera.2014.05.011
