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Because of its potential to enhance metabolic efficiency and endurance, MOTS-c is on the WADA Prohibited List in category S4

These inhibitors were designed based on the knowledge of the mechanisms of catalysis and crystal structure of CD38 and are considered mechanistic/structural-based inhibitors

2015;2(5)doi:10.15406/mojor.2015.02.00068 Kim SJ, Lee HY

Findings were categorized into motor symptoms (such as gait disturbances and neuropathy), non-motor symptoms (focusing on cognitive decline), pathophysiological mechanisms (based on molecular pathways, neuropathology, metabolites and genes), and therapeutic implications (Vit B12 supplementation, clinical recommendations)

Vitamin D supplementation and fracture risk: A meta-analysis of randomised controlled trials