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Curcumin, a polyphenolic curcuminoid with its protective effects and molecular mechanisms in diabetes and diabetic cardiomyopathy
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Chemical research in toxicology, 2007, 20(9): 1309- 1314
It can inhibit a key step of the folate cycle (at the level of 5-methyltetrahydrofolate), leading to the accumulation of AICAR a natural analog of AMP that potently activates AMPK
The common therapeutic approach for these disorders is aimed at regulating circulating GH and IGF-1 levels using recombinant hormone therapy,8 but ongoing in vitro and in vivo studies are employing newer methods of treatment
