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Oxidative stress in OA pathophysiology It has long been suggested that OA arises from a cluster of multiple factors including genetic predisposition, obesity, trauma, aging and even the presence of other systemic diseases

Notably, the enzyme has been linked to obesity and type 2 diabetes (T2D)

Borthakur G , Popplewell L, Boyiadzis M, Foran J, Platzbecker U, Vey N, Walter RB, Olin R, Raza A, Giagounidis A, Al-Kali A, Jabbour E, Kadia T, Garcia-Manero G, Bauman JW, Wu Y, Liu Y, Schramek D, Cox DS, Wissel P, Kantarjian H

Additionally, the evolutionary relationship between P

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