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Inflammation Regulation Chronic low-grade inflammation (inflammaging) contributes to pigmentation issues, acne flares, sensitivity and accelerated aging

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In addition, glutamic acid 46 (E46) and arginine 72 (R72) of HLA class II are essential for a stable interaction between Gp2 and MHC-II, where R72 is conserved in all HLA-DR,-DP alleles, but E46 is conserved in all HLA-DR,-DP alleles and only in a small subset of HLA-DQ alleles: * 02 ( * 0201, * 0202, and * 0203) [219,220,221]