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Repression of Nrf2 by Keap1 The best studied negative regulator of Nrf2 is Keap1, a dimeric protein that is located principally in the cytoplasm [239]

Nevertheless, the precise role of ASS1 in OSCC is rarely mentioned

Indeed, GSH covalently binds to some drug molecules in a GST-dependent manner leading to their cellular export and quenches reactive oxidative species often requiring for these compounds to act [27, 28]

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