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Preclinical models used oral dosing at 50100mg/kg body weight, but human-equivalent subcutaneous protocols typically range from 30mg to 50mg per injection, administered once daily

3 Case Presentation A 24-year-old woman presented with complaints of unsteady gait, generalized fatigue, and bilateral lower limb swelling lasting for over a week

Microb Pathog 47(6):299304 Andersen-Nissen E, Smith KD, Strobe KL, Barrett SLR, Cookson BT, Logan SM, Aderem A (2005) Evasion of Toll-like receptor 5 by flagellated bacteria

That's the evidence base

This article explains why the combination makes sense biologically, what the clinical evidence shows