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But these statistics are the results of observational studies

Malic enzymes ME participate in reactions that link the components of catabolic metabolism in glycolysis and the Krebs cycle via the oxidative decarboxylation of malate to pyruvate, thereby inducing the anabolic metabolism with concomitant NADPH production
[DOI] [PubMed] [Google Scholar] 62.Mauriz J

It is believed that glutathione arose initially in the prokaryotic ancestors of mitochondria and chloroplasts and was acquired by eukaryotes along with these organelles