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These usually develop gradually, but can worsen if the condition goes untreated
Despite the positive roles of microglia in response to cuprizone, a complete absence of microglia prevents cuprizone toxicity suggesting that these cells are also pathogenic during cuprizone-induced demyelination [189]

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Using an elegant approach based on biological nanopore sensors incorporated into artificial lipid membranes, the authors monitored the escape of various substrates from the pore
Adequate protein intake and appropriate supplementation can help manage energy levels during adaptation