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These differences could be explained by the study design (retrospective observational study vs prospective randomized trial), selection bias (subjects from the real-world clinical practice are less selected than those included in a clinical trial), drug compliance (subjects enrolled in a clinical trial perform several on site evaluation in which compliance is verified by tablets accounting, while in clinical practice this is not done)

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Extinction training after cocaine self-administration influences the epigenetic and genetic machinery responsible for glutamatergic transporter gene expression in male rat brain

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