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However, the hepatic levels of cysteine and its metabolites, such as hypotaurine, taurine, and GSH, are increased despite inhibition of the transsulphuration of homocysteine to cysteine in non-obese type-2 diabetic Goto-Kakizaki rats [57]
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On the contrary, MC4R agonist, setmelanotide, was approved for the rare MC4R-deficiency, BardetBiedl syndrome (BBS), with severe obesity in childhood [10, 23]
