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A multicenter RCT, the PIVENS 262 trial, randomized 247 nondiabetic patients treated with MASH into the pioglitazone, vitamin E, and placebo groups for 96 weeks
SIRT1, a key metabolic factor in energy regulation, can stimulate various endocrine signals related to lipid metabolism
This makes the arginate version significantly more stable in liquid and across various pH levels, especially in the acidic environment of the stomach
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