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3 There has been controversy over the classification of NAC as a licensed medicine or a supplement in the USA, and the US Food and Drug Administration (FDA) excluded NAC from the dietary supplement definition in 2020

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Biochim Biophys Acta 63:210212 Ueki I, Roman HB, Valli A, Fieselmann K, Lam J, Peters R, Hirschberger LL, Stipanuk MH (2011) Knockout of the murine cysteine dioxygenase gene results in severe impairment in ability to synthesize taurine and an increased catabolism of cysteine to hydrogen sulfide

[4] Discovery of an oral, rule-of-5 compliant, IL-17A protein-protein interaction modulator (PPIm) for the treatment of psoriasis and other inflammatory diseases