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Splitting the dose flattens the AUC curve and lowers that peak

[DOI] [PMC free article] [PubMed] [Google Scholar] 71.Margolis E.B., Moulton M.G., Lambeth P.S., OMeara M.J

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These matrix changes may render the degenerated IVD as a more brittle stiffer tissue with less dynamic compliancy properties under load and more prone to the development of fissures in the IVD, further compromising its normal biomechanical functions (Vergroesen et al., 2015)

Small data challenges of studying rare diseases