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This shift in body composition can positively affect testosterone levels, as excess body fat is associated with lower testosterone

10.1038/ni.3443 [DOI] [PMC free article] [PubMed] [Google Scholar] 37.Moyron-Quiroz JE, Rangel-Moreno J, Kusser K, Hartson L, Sprague F, Goodrich S, et al

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This decline in antioxidant enzyme activity further exacerbates ferroptosis (33, 35), leading to uncontrolled lipid peroxidation, accelerating myocardial cell death, and triggering myocardial fibrosis and heart dysfunction (36)

In a clinical setting this could be implemented with advice to consume foods that have some evidence to suggest they improve glutathione status such as lean protein sources, brassica vegetables, polyphenol-rich fruits and vegetables, herbs and spices, green tea, and omega-3 fatty acid rich-foods such as fish