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In the 24-week, placebo-controlled factorial study of initial therapy with JANUVIA in combination with metformin, the incidence of hypoglycemia was 0.6% in patients given placebo, 0.6% in patients given JANUVIA alone, 0.8% in patients given metformin alone, and 1.6% in patients given JANUVIA in combination with metformin

Tirzepatide Reduced the Risk of Developing Type 2 Diabetes by 94% in Adults with Pre-diabetes and Obesity or Overweight

Overall, the presence of GLP-1R in these reward-related brain regions suggests that GLP-1 signaling may play a significant role in modulating reward processing and addictive behaviors [6]