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This release of histamine and tryptase increases blood flow to the skeletal muscles during exercise.[ref] Hypoxia has also been shown to induce mast cell degranulation.[ref] This is a normal response for most people, and the body can handle a certain increase in histamine and tryptase

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In addition to their roles in neurotransmitter synthesis and homocysteine regulation, B vitamins are also critical for reducing oxidative stress and inflammation, which are central to the aging process and the development of neurodegenerative diseases like Alzheimers, Parkinsons, and Huntingtons disease

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Deficiencies are linked to Alzheimer's/Dementia, Parkinson's, Cancers, Auto-Immune, Cardiovascular Disease, Diabetes, Mast Cell Activation Syndrome, and so much more