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These disappointing observations raised the question of why HER2 blocking agents failed to improve the survival of OAC patients, despite achieving clinical success in breast cancer

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52 For an ideal assessment of the type, quantity, and frequency of food intake, real-time monitoring would be preferable over methods such as 24-hour dietary recalls or short-term measurements of food consumption

Patients who experience persistent palpitations beyond 8 weeks at a stable dose should undergo formal cardiac evaluation, including ECG and Holter monitoring, to rule out atrial fibrillation or other arrhythmias that GLP-1 therapy may have unmasked rather than caused

In research protocols, this can be either desirable (for models examining appetite regulation, weight gain, or catabolic disease states) or undesirable (for protocols where appetite stimulation is a confounder)