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Researchers at Monash University recognized that many individuals seeking fat loss could not tolerate or did not need growth hormones broader effects including muscle growth, glucose elevation, and IGF-1 stimulation

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Nature Reviews Endocrinology: The effects of growth hormone on adipose tissue: old observations, new mechanisms Multidisciplinary Digital Publishing Institute: Central Regulation of Metabolism by Growth Hormone Medical Anti-Aging: Sermorelin Medical Evidence Journal of Anti-Aging Medicine: Growth Hormone Releasing Hormone Treatment in Normal Aging Translational Andrology and Urology: Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males Springer Nature Link: Effects of growth hormone therapy on bone density and fracture risk in age-related osteoporosis in the absence of growth hormone deficiency: a systematic review and meta-analysis

The lethal dose in humans would be approximately 21,000mg for a 70kg person, making the 1-3mg daily doses used in typical protocols extremely safe from a toxicity standpoint