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1 Introduction Mitochondria are the primary organelles responsible for energy production ( Skeletal muscle relies on mitochondria to generate ATP through OXPHOS, providing energy for muscle contraction and sustained activity ( When mitochondrial OXPHOS function is impaired, it cannot meet cellular energy demands, leading to metabolic disorders and a range of diseases ( Mutations in either the nDNA or mtDNA genomes within mitochondria can disrupt ETC complexes

Cognitive-behavior therapies are suggested to avoid relapses [30]

high-fat diets) and by fasting