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In Phase I metabolism, paracetamol is primarily metabolized by the enzyme CYP2E1, resulting in the formation of a toxic metabolite called N-acetyl-p-benzoquinonimine (NAPQI)

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But that's a terribly incomplete answer

Persistent hyperglycemia results in the activation of the Polyol (Sorbitol) pathway (see Fig

Advances in next-generation sequencing have expanded the catalog of such patterns, enabling more precise attribution of cancers to environmental causes [129]
