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Mutations in PUS1 are associated with the rare disorder myopathy, lactic acidosis, and sideroblastic anemia (MLASA)
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Additionally, methylation is also integral to how we function every second of the day
Hypoxia affects T cell migration and retention by downregulating chemokines (e.g., CXCL9/10) necessary for T cell recruitment and upregulating CXCL12, which retains T cells in the stroma, away from tumor nests [73, 74]
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