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Side-effect patterns are different by route

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In 2019, the FDA issued a warning against using ozone therapy, citing potential toxicity and limited proven therapeutic benefits
Sao Paulo Med J 127:270277 Horton JD, Dezee KJ, Ahnfeldt EP, Wagner M (2008) Abdominal wall endometriosis: a surgeons perspective and review of 445 cases

Poor nutrition: Vegan and strict vegetarian diets usually lack B12, unless supplements or fortified food are consumed