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Thus, current limitations concerning intralesional collagenase are of a high expenditure, and have an uncertain effect on specific patients with severe curvature and extensive calcification ( Topical Medication Topical approaches for drug delivery for PD were used due to its simplicity, painlessness, and safety

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This state of leaky gut is associated with chronic systemic inflammation, characterized by elevated proinflammatory cytokines, including TNF, IL6, and IL1, which contribute to myocardial remodeling and cardiac dysfunction and can exacerbate HF symptoms and severity (Tang et al

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