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Proper disposal of expired or unused medication is critical
(iii) pyruvate, which is the primary fuel for the mitochondrial respiratory chain and adenosine triphosphate (ATP) production in these organelles [13]

The above-mentioned approach of functional MRS may also be helpful as it may reflect better the immediacy of fatigue and PEM, characteristic for ME/CFS
Quinlan et al., 2013), complex I and complex III (Venditti et al., 2013) have been shown to be the most important sources of mitochondrial superoxide generation, although significant production of ROS in complex II has recently also been reported (Quinlan et al., 2012)

Once they enter the cells, they will begin transcription of IFN and pro-inflammatory cytokines, respectively
