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In preclinical studies of COX-2 selective inhibitors, suppression of PGE2 at the inflammatory site with no change in serum TXB2 confirms COX-2 selectivity, while suppression of both indicates non-selective COX inhibition

Mitochondrial oxidative damage and increased oxidative stress are typical in renal tissues

doi: 10.1097/CEJ.0000000000000194 369

HSPA2 influences the differentiation and production of immunomodulatory mediators in human immortalized epidermal keratinocyte lines