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NAD is a coenzyme central to mitochondrial function, DNA repair, and sirtuin activation

Acknowledgments The authors thank Quanlong Zhang, Linlin Wang, Xinxiu Liu, Jin Li, Jing Cao and Xiaowei Cao for providing the literature search and material organization, and Guiying Hu for organizing the consensus conference and revision of the manuscript

Acknowledgments The study was supported by the Suzhou Special Project of Diagnosis and Treatment for key Clinical Disease (LCZX201814) and Suzhou Association of Integrated Traditional and Western Medicine (SYSD2018208)

You are unable to maintain adequate nutrition because of appetite suppression

The role of betaine in the methylation process becomes more crucial under conditions of folate deficiency such as excessive alcohol consumption that impairs folate metabolism and interferes with folate-dependent methylation [158,159]