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Oncotarget 7 , 3383233840 (2016)

A negative MTT, resazurin, ATP-luminescence, or LDH-release result can only show that overt cytotoxicity was not detected under a defined cell type, exposure time, concentration, vehicle, and assay condition

This makes it difficult to accurately predict in vivo behavior from laboratory data, necessitating more extensive animal and human trials (153)

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This results in inflammation and swelling of the nerves and soft tissues