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The application of ADP resulted in the occurrence of a potassium current reversing around 77.0 3.7 mV ( n = 4) which exhibited an inward rectification at high voltages and a high sensitivity to 20 mM tetraethyl ammonium (TEA, Figure 7A)

However, administration of calcitriol or activation of renal calcium reabsorption by a retinoid derivate restored plasma IGF-1 levels.110 Importantly, chondrocytes isolated from rats with renal insufficiency also show decreased response to the anabolic effects of IGF-1 compared to chondrocytes from rats with normal renal function,111 suggesting that intracellular alterations as causing factors for IGF-1 resistance

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