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These interactions suggest that polyphenolic compounds may collectively target core AD mechanisms, including neuroinflammation, tau phosphorylation, and amyloidbeta aggregation

Polyspecificity - An emerging trend in the development of clinical antibodies

Substitution of key leucine residues (L145, L149, and L152) in the hydrophobic interface with tryptophan (1933 and 2007), significantly reduced peptide activity, indicating that these leucine residues are required for interaction with the hydrophobic pockets of FAT

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