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Interestingly, S586A displayed an over 2-fold improvement in activity compared with the WT enzyme (96.0 2.0 Umg 1 versus 43.1 1.0 Umg 1 ), representing the highest activity among all variants tested

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Xie Y, Lowry WE., "Manipulation of neural progenitor fate through the oxygen sensing pathway", Methods (2017)
