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Based on this, an investigator-initiated, phase III, double-blind, randomized controlled trial was performed to evaluate the efficacy and safety of high-dose selenium (2000 g/day) intravenously in a 1:1 ratio for the prevention of CIPN in 68 platinum-sensitive cancer patients treated with paclitaxel, carboplatin, and bevacizumab [110]
However, there were many flaws in the study-plasma GSH levels were not measured (as bioavailability of oral GSH is low), limited study period of 4 weeks, no follow-up to determine when the skin melanin indices return to their baseline values, medical students were chosen (young, otherwise healthy population) and the study was conducted during their college time to ensure that sun exposures were minimal
Lactic Acid and Vitamin C Although lactic acid is one of the milder AHAs, if not appropriately combined, it can dilute vitamin C
M.KaczorA.PilarczykM.BaranskaM
10.1371/journal.pone.0129621 110 ZhangQ.WangC.LiuZ.LiuX.HanC.CaoX.et al (2012)
