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This study demonstrated that sequestration of NRF2 by progerin, which results in protein mislocalization and the impairment of NRF2-mediated antioxidant response, contributes to progerin-associated nuclear aging defects [115]

Nat Immunol 4(4):321329 Iwawaki T, Akai R, Yamanaka S, Kohno K (2009) Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability

Inadequate GSH levels compromise immune cell activities, leading to weakened phagocytosis by macrophages, diminished cytotoxicity in NK cells, impaired antigen presentation by dendritic cells, and compromised proliferation and signaling in lymphocytes

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