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To determine whether this ARE is functional to mediate NRF2-dependent upregulation of CBS gene expression, we cloned CBS promoter fragment from 1000 to +200 bp and mutant fragment with deletion of +77 to +87 bp into a pGL3-basic luciferase reporter vector, which were designated as pGL3-phCBS and pGl3-phCBS-ARE, respectively

Current evidence suggests that melatonin has a mitigating effect on the ototoxicity of glyphosate-based herbicides and fenoxaprop-ethyl, and its possible mechanisms include the prevention of glyphosate-based herbicides-induced oocyte deterioration and activation of its downstream signaling events (pERK/ERK) by protecting G-protein estrogen receptor (GPER/GPR30) expression and regulating the levels of regulatory hormones (He et al., 2019a

The pentameric structure of IgM that provides a high valency to the molecule, and the low affinity of IgM polyreactive natural antibodies, both favor agglutination (100-10,000 times more effective than IgG), which is considered as a paramount component of the IgM-mediated virus neutralization

Cardiac fibrosis: myofibroblast-mediated pathological regulation and drug delivery strategies

Hall CN, Klein-Flgge MC, Howarth C, Attwell D