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Previous epidemiological studies have indicated significant differences in CMS prevalence among different ethnic groups, with a notably lower prevalence in Tibetan highlanders compared to Andean highlanders and Han Chinese

Likewise, as occurring with oral supplementation, the bioavailability of polyphenols present in foods is in general low, and in vitro, studies observed clear differences in the mechanisms of polyphenols when used in their pure form and at high concentrations versus when ingested through foods rich in these compounds [600]

doi: 10.1007/s11010-022-04492-3

That approval came with substantial clinical evidence

Caveolins and lung function