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The clarified lysates were loaded onto CAQK-coated Sulfolink-agarose beads (Pierce) and incubated at 4 C for 34 h

EGCG also downregulated the expressions of -SMA, fibronectin, mast cell trypsin, and chymotrypsin, as well as TGF-1, CTGF, and PAI-1 [81] as an emerging potential phytocompound EGCG has come upon with its recently discovered role in fibrosis

Inhibition of the Xc-system determines the decrease in GSH levels, which indirectly leads to the inactivation of GPX4 and the onset of ferroptosis ( 3+ enters cells with the assistance of transferrin and subsequently converts to Fe 2+ ( 2+ can catalyze the generation of metabolically toxic reactive oxygen species and phospholipid peroxide through the Fenton reaction, leading to cell damage or death (Figure 4)

Wanner, I