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Efficacy was related to degree of hypercarnitinemia which is consistent with a deficiency of functional carnitine biosynthesis in the ethanol fed rats [71]

doi: 10.1016/s0022-3476(95)70562-7 45

M., Merinero, B., Wajner, M., Troncoso, M., Williams, M., Walter, J

These miRNAs reside in intronic regions within SREBP-1 and 2, the key transcriptional regulators of lipid metabolism 87 , and control the expression of carnitine O -octanoyltransferase (CROT), CPT1A, hydroxyacyl coenzyme A (hydroxyacyl-CoA) dehydrogenase subunit beta (HADHB), and AMPK, targeting their 3 UTR 88

[3] Carnitine supplements do not seem to improve oxygen consumption or metabolic functions when exercising, nor do they increase the amount of carnitine in muscle