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Description
The pentose phosphate pathway generates NADPH from glucose, while mitochondrial enzymes produce NADPH to support glutathione recycling inside mitochondria [9]
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What's Happening: NAD+ restoration begins affecting mitochondrial function
In a clinical trial, participants with obesity (without diabetes) experienced an average weight loss of 20% with tirzepatide, compared to 13.7% with semaglutide after 72 weeks
