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In fact, superoxide is a signaling molecule that is necessary for vascular function, and Nox4 deficiency, which decreases superoxide levels, decreased angiogenesis and accelerated the development of heart failure (1, 26, 77, 95, 113)

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doi: 10.1371/journal.pone.0075643 [DOI] [PMC free article] [PubMed] [Google Scholar] [250].Coburn J, Magoun L, Bodary SC, et al

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Amino acids combine in different patterns to make all of the proteins in the body